Question

What is the consequences of fluoroacetate inhibiting the Krebs cycle pathway

Answer 1

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➡As the enzymes of the Krebs cycle oxidize fuel molecules to carbon dioxide, the coenzymes NAD + , FAD, and coenzyme Q (also known as ubiquinone) are reduced. In order for the cycle to continue, these reduced coenzymes must become reoxidized by transferring their electrons to oxygen, thus producing water.

➡The Krebs cycle occurs in the mitochondrial matrix and generates a pool of chemical energy (ATP, NADH, and FADH2) from the oxidation of pyruvate, the end product of glycolysis. ... When acetyl-CoA is oxidized to carbon dioxide in the Krebs cycle, chemical energy is released and captured in the form of NADH, FADH2, and ATP.

Importance:-

The Krebs cycle is the second of three stages of cellular respiration, in which glucose, fatty acids and certain amino acids, the so-called fuel molecules, are oxidized (see Figure). The oxidation of these molecules is primarily used to transform the energy contained in these molecules into ATP.