Question

What is the difference and similarities between DNA polymerase I and DNA polymerase III

Answer 1

Explanation:

The DNA polymerase adds dATP, dGTP, dCTP and dTTP to the growing DNA strand while the RNA polymerase inserts dATP, dGTP, dCTP and dUTP to the growing RNA strand. (Because instead of thymine, the RNA contains uracil). Though the function of both polymerases is to synthesise nucleic acid, both are functionally different.

Answer 2

What is the difference between DNA polymerase 1 and 3?

DNA has a leading strand and a lagging strand.

During DNA Replication:

DNA polymerase 3 synthesize DNA from 5' to 3' end on the leading and lagging strand ( but stops at the RNA Primer ) and has exo nuclease activity from 3' to 5' end for proof reading ( kind of a reverse gear )

On the other hand, DNA Polymerase 1 works on lagging strand where it degrades RNA primer and replace it with DNA ( synthesis from 5' to 3' end ) and in contrast with DNA polymerase 3,it has proof reading acivity from 5' to 3' end ( in the same direction )

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