what is the difference between stirred tank bioreactor and sparged stirred tank bioreactor ?
Answers
1.There is increased surface area for oxygen transfer in the Sparged Stirred bio reactor, whereas there is less surface area as compared to Sparged tank for oxygen area in Simple Stirred bio reactors.
2.Bubbles increase the oxygen transfer area in Sparged whereas there is absence of oxygen bubbles in Simple stirred.
Answer:
The major differences between stirred tank bioreactor and sparged stirred tank bioreactor are:-
- There is increased surface area for oxygen transfer in the sparged stirred bioreactor, whereas there is less surface area in simple stirred bioreactor for oxygen transfer as compared to Sparged tank bioreactor.
- Presence of bubbles increases the oxygen transfer area in sparged stirred bioreactor whereas there is the absence of oxygen bubbles in simple stirred bioreactor
Explanation:
A bioreactor is a cylindrical tank which is used to carry out large-scale biological operations. It is used to cultivate host cells in order to obtain desired products in recombinant DNA technology. Although just a little amount of the desired product is created in the laboratory, large-scale manufacturing requires bioreactors. Raw materials are biologically transformed into particular products, individual enzymes, and other items in this process. Pharmaceuticals, vaccines, and antibodies are all made with it. The most common type is the stirring bioreactor.
There are two types of stirred bioreactors:
- Simply stirred tank bioreactors,
- Sparged stirred-tank bioreactors
A stirred-tank reactor includes a cylindrical or curved base that facilitates the mixing of reactor material, and the stirrer aids in consistent mixing and oxygen availability throughout the bioreactor.
The sterile air is sparged through the reactor in a sparged stirred-tank bioreactor. The surface area of a sparged stirred-tank bioreactor for oxygen transfer is greater than that of a standard stirred-tank bioreactor.
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