What is the effect of carbon monoxide poisoning on cytochromes?
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ᴄᴀʀʙᴏɴ ᴍᴏɴᴏxɪᴅᴇ ɪꜱ ᴛᴏxɪᴄ ꜰᴏʀ ᴍɪᴛᴏᴄʜᴏɴᴅʀɪᴀ ɪɴ ᴍᴀɴ, ᴀʟᴛᴇʀɪɴɢ ᴛʜᴇ ᴍɪᴛᴏᴄʜᴏɴᴅʀɪᴀʟ ʀᴇꜱᴘɪʀᴀᴛᴏʀʏ ᴄʜᴀɪɴ ᴀᴛ ᴛʜᴇ ᴄʏᴛᴏᴄʜʀᴏᴍᴇ ᴄ ᴏxɪᴅᴀꜱᴇ ʟᴇᴠᴇʟ. ᴛʜɪꜱ ɪɴʜɪʙɪᴛɪᴏɴ ɪɴ ᴄʏᴛᴏᴄʜʀᴏᴍᴇ ᴄ ᴏxɪᴅᴀꜱᴇ ᴍᴀʏ ᴘʟᴀʏ ᴀ ʀᴏʟᴇ ɪɴ ᴛʜᴇ ᴅᴇᴠᴇʟᴏᴘᴍᴇɴᴛ ᴏꜰ ᴛʜᴇ ꜱʏᴍᴘᴛᴏᴍꜱ ᴏʙꜱᴇʀᴠᴇᴅ ɪɴ ᴀᴄᴜᴛᴇ ᴄᴏ ᴘᴏɪꜱᴏɴɪɴɢ, ᴀɴᴅ ɪɴ ꜱᴏᴍᴇ ᴅɪꜱᴇᴀꜱᴇꜱ ʀᴇʟᴀᴛᴇᴅ ᴛᴏ ꜱᴍᴏᴋɪɴɢ.
Answer:
☆Carbon monoxide (CO) toxicity is the result of a combination of tissue hypoxia and direct CO-mediated damage at a cellular level, since not all the signs and symptoms presented can be explained only by the formation of carboxyhaemoglobin. Mitochondria, specially the electron transport chain, seem to be the target for CO at a subcellular level. However, the direct effect of CO in individual complexes of the human mitochondrial respiratory chain has not been completely elucidated. We here studied the in vitro effect of CO on individual complexes of the mitochondrial respiratory chain of human mitochondria.
☆Carbon monoxide is toxic for mitochondria in man, altering the mitochondrial respiratory chain at the cytochrome c oxidase level. This inhibition in cytochrome c oxidase may play a role in the development of the symptoms observed in acute CO poisoning, and in some diseases related to smoking.
Explanation:
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