What is the fate of pyruvate before entering into cyclic pathway
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When sufficient oxygen is not present in the muscle cells for further oxidation of pyruvate and NADH produced in glycolysis, NAD+ is regenerated from NADH by reduction of pyruvate to lactate.
Lactate is converted to pyruvate by the enzyme lactate dehydrogenase. ... NADH is oxidized to NAD+ during this reaction.
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Breakdown of Pyruvate
In order for pyruvate, the product of glycolysis, to enter the next pathway, it must undergo several changes to become acetyl Coenzyme A (acetyl CoA). Acetyl CoA is a molecule that is further converted to oxaloacetate, which enters the citric acid cycle (Krebs cycle).
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