What is the folding code for denatured proteins? And can we predict the native structure of a protein from its amino acid sequence precisely?
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For your first question, it is still under research. Scientists have not yet been able to find the code for the folding of proteins, although they speculate that the starting point of protein folding is indeed the primary structure (the sequence of amino acids), also known as denatured state of the protein. Even the smallest amount of the denatured state can activate nucleation and proliferation carried out through protein folding pathways. Characterization of these denatured states of proteins at physiological conditions is very difficult because it is necessary to unfold the proteins to their denatured states without the presence of denaturants
Recent research has allowed the study of denatured states to reach new heights using the single-molecule approach. Researchers used single-molecule experiments to examine coil to globule transition of proteins and have demonstrated that the denatured state showed steady expansion as the concentration of denaturant was increased.
Also there have been advancements to study intermediates in protein folding.
Although the folding of protein is still an enigma, scientists have taken the advantage of these protein information to design new materials, such as medicine, reagents and inhibitors, to benefit the society.
Perhaps you could later on create your mark in this field....
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