what is the function of koofer cell???
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Role of Kupffer cells in host defense and liver disease. ... They reside within the lumen of the liver sinusoids, and are therefore constantly exposed to gut-derived bacteria, microbial debris and bacterial endotoxins, known to activate macrophages.
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Kupffer cells (KC) are tissue-resident macrophages residing in the liver.
They are located in the liver sinusoids, and are the largest population of innate immune cells in the liver .
Due to their abundance and localization, KC are crucial cellular components of the intrahepatic innate immune system that are specialized to perform scavenger and phagocytic functions, thereby removing protein complexes, small particles, and apoptotic cells from blood.
They are located in the liver sinusoids, and are the largest population of innate immune cells in the liver .
Due to their abundance and localization, KC are crucial cellular components of the intrahepatic innate immune system that are specialized to perform scavenger and phagocytic functions, thereby removing protein complexes, small particles, and apoptotic cells from blood.
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