Question

What is the impact of hydrophobicity of small molecule on ligand-protein interaction

Answer 1

Together, these results show that fragments are using polar interactions to gain maximum binding efficiency from a limited number of interactions, but as small-molecule ligands are optimized, geometric constraints associated with polar bonds are more challenging to satisfy, and the contribution of hydrophobic

Answer 2

Together, these results show that fragments are using polar interactions to gain maximum binding efficiency from a limited number of interactions, but as small-molecule ligands are optimized, geometric constraints associated with polar bonds are more challenging to satisfy, and the contribution of hydrophobic