what is the major difference between optical spectroscopy and vibrational spectroscopy?
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Vibrational spectroscopy has immense importance as an important tool in the pharmaceutical application, where this spectroscopy technique encompasses Fourier Transform infrared (FT IR), Raman and near-infrared spectroscopy. These techniques are sensitive to the chemical structure of the compound and to the environment, where the bond vibrations are measured as an analyzing parameter (Jamieson and Byrne, 2017). Thus, the changing of vibration can help in the determination of solid-state characterization behavior of API and also as a potential probe to determine intermolecular interaction among different ingredients (Volpati et al., 2014). Therefore, any pharmaceutical interaction type, including dehydration or hydrate formation, desalting, morphological changes, or interchange between amorphous and crystalline can easily be identified by this technique.