What is the most common site of first pass metabolism of drugs
Answers
First Pass Metabolism
Drugs that are administered orally (as opposed to intravenously, intramuscularly, sublingually, or transdermally) must first pass from the intestine to the liver before reaching the general circulation. Thus, for many drugs, much of the dose is reduced by xenobiotic metabolism before reaching the tissues. Since some drugs are metabolized by gut flora or digestive enzymes, the first-pass effect refers to the combined effect of metabolism by the liver and in the gut.
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Answer:
First pass metabolism may occur in the liver (for propranolol, lidocaine, clomethiazole, and GTN) or in the gut (for benzylpenicillin and insulin). After a drug is swallowed, it is absorbed by the digestive system and enters the hepatic portal system.