. What is the principle of immunization?
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The basic theory of immunization is that the body begins to produce antibodies against it upon administration of the vaccine so that the individual is safe from disease.
In 1798 Edward Jenner introduced inoculation with cowpox (smallpox vaccine), a much safer procedure. This procedure, referred to as vaccination, gradually replaced smallpox inoculation, now called variolation to distinguish it from vaccination.
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