What is the relationships between structure and function in coronin?
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Until recently, structural information about coronins was scarce and the earlier identification of five WD40 repeats gave rise to a structural prediction of a five-bladed β propeller for the N-terminal domain of these proteins. More detailed analyses revealed the presence of seven WD40 repeats and the hypothesis of a seven-bladed β propeller structure. This model has recently been validated due to structural information from crystal structures of C-terminally truncated coronin 1 (1A), as well as its C-terminal coiled coil domain. Further structural information is available only indirectly from binding and functional studies.
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