What is the role of a histone within the chromosome? How does the charge of the DNA molecule react with the charge of the histone?
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DNA Packaging in eukaryotes is carried out with help of Lysine and Arginine rich basic proteins called Histones. The unit of compaction is nucleosome. There are 5 types of histone proteins H1, H2A, H2B, H3 and H4.
Four of them occurs in pairs to produce histone octamer( 2copies of each H2A, H2B, H3 and H4) called nubody or core of nucleosome. Their positively charged ends are directed outwards. The negatively charged DNA is wrapped around the positively charged histone octamer to form a structure called nucleosome . A typical nucleosome contains 200bp of DNA helix. DNA present between two nucleosome is called linker DNA . It is attached to H1 histone protein.
Four of them occurs in pairs to produce histone octamer( 2copies of each H2A, H2B, H3 and H4) called nubody or core of nucleosome. Their positively charged ends are directed outwards. The negatively charged DNA is wrapped around the positively charged histone octamer to form a structure called nucleosome . A typical nucleosome contains 200bp of DNA helix. DNA present between two nucleosome is called linker DNA . It is attached to H1 histone protein.
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