Question

what is the role of coordinator compounds in medical chemistry

Answer 1

•Excess of some metals can be removed by chelating ligands. Eg:- Excess of Copper and Iron can be removed by D-penicillamine and desferrioxime B by forming coordination compounds with them. EDTA is used in the treatment of lead poisoning.
• Some coordination compounds inhibit the growth of tumours hence are used as anti cancer drugs. Eg:- cis-platin.

Hope it helps.

Answer 2

(6)- lanthanum carbonate

(7) - Metals in medicine and in food. Synthetic coordination compounds with active drugs as ligancoordination compounds; whereas [AlCl4]− and [FeF6]3− are coordination complexes in which the coordination number exceeds the oxidation number. The chromate anion, CrO4=, is not a coordination complex; the o.n. of the Cr atom is 6, but only four O atoms are bonded to it.

Application of coordination compounds
Coordination compounds are found in living systems and have many uses in the home ,in industry, and medicine. We describe a few example here and in the chemistry.

Coordination compounds play many roles in the animals and plants.they are essential in the storage and transport of oxygen, as electron transfer agent ,as catalysts, and in photosynthesis. here we focus on coordination compounds containing iron and magnesium .

Because of its central function as an oxygen carrier for metabolic processes, hemoglobin is probably the most studied of all the proteins. The molecule contains four folded long chains called subunits . hemoglobin carriers oxygen in the blood from the lungs to the tissues, where it delevers the oxygen molecules to myoglobin,. Myoglobin, which is made up of only one subunit, stores oxygen for metabolic process in muscle .

The porphine molecule from an important part of the hemoglobin structure . upon coordination to a metal , the H+ ions that are bonded to two of the four nitrogen atoms in porphine are displaced . complexes derived

porphine

Simplified structure of the porphine molecule and the Fe2+ -porphyrin complex. The dashed lines represented coordinate covalent bonds.

From porphine are called porphyrins, and the iron-porphyrin combination is called the home group. The iron in the home group has an oxidationnumber +2 , it is coordinated to the four nitrogen atoms in the porphine group and also to a nitrogen donor atom in a ligand that is attached to protein. The sixth lingand is a water molecule , which bind to the Fe2+ ion on the other side of the ring to complete the octahedral complex. This hemoglobin molecule is called deoxhemoglobine and imparts a bluish tinge to venous blood. The water ligand can be replaced readily by molecular oxygen to from red oxyhemoglobine found in arterial blood. Each subunit Contains a heme group , so each hemoglobin molecule can bind up to four O2 molecules.

There are three possible structure for oxyhemoglobin. For a number of year , the exact arrangement of the oxygen molecule relative to the porphyrin group was not clear .most experiment evidence suggest that the bond between O and Fe is bent relative to the heme group.

The porphyrin group is a very effective chelating agent , and not surprisingly , we find it in anumber of biological systems. The iron-heme complex is present in an other class of protins,called the cytochromes. The iron from a octahedral complex in these proteins, but because both the histidine and the methionine groups are firmly bound to the metal ion,they cannot be displayed by oxygen or other ligands,instead, the cytochromes act as electron carriers, which are essential to metabolic processes.in cytochromes ,iron undergoes rapid reversible redox reaction:

Fe3+ + e- ------- Fe2+