what is the role of protein binding in physiologic process handling the drugs in living body with example
Answers
Explanation:
Physiologic factors that can influence drug–protein binding include age, gender, pregnancy, and others. Since concentrations of both albumin and alpha-1-acid glycoprotein in neonates are lower than adults and the higher concentrations of fatty acids and bilirubin which are both normal substances that bind albumin, drug-binding to albumin and alpha-1-acid glycoprotein is lower in neonates. Albumin concentration in the elderly is also lower compared to normal adults. Also, a higher percentage of glycosylated albumin is found in the elderly which accounts for the observed decreased binding of albumin-binding drugs. Another physiologic factor is gender, the concentration of both albumin and alpha-1-acid glycoprotein are found to be lower in adult females (nonpregnant) as compared to adult males which explains the slight decrease in the bound fraction of some drugs. During pregnancy (mainly in the third trimester), alterations in the binding of albumin-binding drugs can occur. Since albumin concentration is lower and there is an increase in the concentration of free fatty acids, the binding of albumin-binding drugs is reduced, and higher unbound fractions are observed