What is the significance of hypnozoites with reference to malaria fever?
Answers
Answered by
0
❣️Hey Dost❣️
➡️Plasmodium vivax malaria is characterized by periodic relapses of symptomatic blood stage parasite infections likely initiated by activation of dormant liver stage parasites -hypnozoites. The lack of tractable animal models for P. vivax constitutes a severe obstacle to investigate this unique aspect of its biology and to test drug efficacy against liver stages. We show that the FRG KO huHep liver-humanized mice support P.
___________________________
Shinchan #
➡️Plasmodium vivax malaria is characterized by periodic relapses of symptomatic blood stage parasite infections likely initiated by activation of dormant liver stage parasites -hypnozoites. The lack of tractable animal models for P. vivax constitutes a severe obstacle to investigate this unique aspect of its biology and to test drug efficacy against liver stages. We show that the FRG KO huHep liver-humanized mice support P.
___________________________
Shinchan #
Answered by
0
Life cycle of some parasitic protozoa of the phylum Apicomplexa inlcudes the dormant forms are the hypnozoites and they are known for their link with latency and relapse occurring during human malarial infections caused by malarial parasites such as Plasmodium ovale and P. vivax. When infected mosquitoes are kept at cold temperature, more hypnozoites are produced. Dormancy period variations occurring in hypnozoites is a polymorphic trait in P. vivax, and relapse time variations are a result of regional and seasonal variation in the mosquito vector.
Similar questions