Question

What is the Urea Cycle?

Answer 1

In humans and mammals, almost 80% of the nitrogen excreted is in the form of urea, which is produced through a series of reactions occurring in the cytosol and mitochondrial matrix of liver cells. These reactions are collectively called the urea cycle or the Krebs-Henseleit cycle.

Ammonia is a toxic product of nitrogen metabolism which should be removed from our body. The urea cycle or ornithine cycle converts excess ammonia into urea in the mitochondria of liver cells. The urea forms, then enters the blood stream, is filtered by the kidneys and is ultimately excreted in the urine.

The overall reaction for urea formation from ammonia is as follows:

2 Ammonia + CO2 + 3ATP ---> urea + water + 3 ADP

Answer 2

The Urea cycle is also called the 'Ammonia detox cycle' and this is the process of removal of ammonia from the body. Ammonia is the end product of protein metabolism, which is toxic to the human body, especially the CNS.


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