Question

what is Thrombopoiesis?​

Answer 1

Answer:

Thrombopoiesis is the process of development of thrombocytes. Thrombocytes are also known as platelets. Platelets, along with clotting factors, form blood clot thereby preventing loss of blood from the body. The process of formation of RBCs is known as erythropoiesis.

Answer 2

Answer:

The process of blood clot formation.

                 (OR)

The formation of blood platelets.

Explanation:

• Thrombopoiesis is the formation of platelets in the Bone marrow.

• Thrombopoietin is the main regulator of thrombopoiesis.

This includes self-renewal and expansion of hematopoietic stem cells, stimulating the increase of megakaryocyte progenitor cells, and supporting these cells so they mature to become platelet-producing cells.

• Thrombopoiesis—from thrombos (Gr., clot)—refers to the production of platelets, which are small (2 to 4 µm), round to ovoid, anucleate cells within blood vessels.

Steps of thrombopoiesis:

1. A hemocytoblast gives rise to a common myeloid progenitor cell (CMP).
2. The CMP gives rise to CFU-Meg (or CFU-Mega, the colony-forming unit that leads to the formation of megakaryocytes).
3. The CFU-Meg develops into a megakaryoblast.
4. The megakaryoblast develops into a promegakaryocyte.

The stem cell for thrombopoiesis:

Impaired thrombopoiesis leads to increased plasma thrombopoietin (TPO) levels and perturbed hematopoietic stem cells (HSCs).

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