what is thyroxine and explain hyposecration and hypersecration of thyroxine
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- Thyroid hormones are two hormones produced and released by the thyroid gland, namely triiodothyronine (T3) and thyroxine (T4).
- They are tyrosine-based hormones that are primarily responsible for regulation of metabolism.
- T3 and T4 are partially composed of iodine. A deficiency of iodine leads to decreased production of T3 and T4, enlarges the thyroid tissue and will cause the disease known as simple goitre.
- The major form of thyroid hormone in the blood is thyroxine (T4), which has a longer half-life than T3.
Overproduction or underproduction of a pituitary hormone will affect the respective end-organ. For example, insufficient production (hyposecretion) of thyroid stimulating hormone (TSH) in the pituitary gland will cause hypothyroidism, while overproduction (hypersecretion) of TSH will cause hyperthyroidism.
The release of too much thyroxine in the bloodstream is known as thyrotoxicosis. This may be caused by overactivity of the thyroid gland (hyperthyroidism), as in Graves' disease, inflammation of the thyroid or a benign tumour.
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