what is TRPM5 ...??
you can take help from Google añd give answer in simple language.!
Answers
Explanation:
TRPM5 is a calcium-activated non-selective cation channel that induces depolarization upon increases in intracellular calcium, it is a signal mediator in chemosensory cells. Channel activity is initiated by a rise in the intracellular calcium, and the channel permeates monovalent cations as K+ and Na+.
I hope this may help you
Explanation:
here.is ur answer
TRPM5 expresses at high levels in taste tissue and co-localizes with other known elements of the gustatory signaling pathway, including α-gustducin. The T1R and T2R G-protein-coupled taste receptors initiate a common signaling pathway involving PLCβ2 and TRPM5 to encode sweet, umami (amino acid), and bitter taste sensations. This finding indicates that TRPM5 is a common taste transduction element involved in relaying information from a subset of different taste receptors. Studies focusing exclusively on heterologously expressed TRPM5 indicate that the current is a voltage-modulated, monovalent-selective cation conductance that is activated by micromolar levels of intracellular Ca2 +. Receptor stimulation upstream of PLCβ2 (which co-localizes with TRPM5) generates IP3 and thereby increases intracellular [Ca2 +] to a level that triggers ion flux through TRPM5....