What is trypsin? what is its function ? ANSWER FAST GUYS.....!!
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- ❤❤ᴛʀʏᴘsɪɴ ɪs ᴀ ᴘʀᴏᴛᴇᴏʟʏᴛɪᴄ ᴇɴᴢʏᴍᴇ, ɪᴍᴘᴏʀᴛᴀɴᴛ ғᴏʀ ᴛʜᴇ ᴅɪɢᴇsᴛɪᴏɴ ᴏғ ᴘʀᴏᴛᴇɪɴs. ɪɴ ʜᴜᴍᴀɴs, ᴛʜᴇ ᴘʀᴏᴛᴇɪɴ ɪs ᴘʀᴏᴅᴜᴄᴇᴅ ɪɴ ɪᴛs ɪɴᴀᴄᴛɪᴠᴇ ғᴏʀᴍ, ᴛʀʏᴘsɪɴᴏɢᴇɴ, ᴡɪᴛʜɪɴ ᴛʜᴇ ᴘᴀɴᴄʀᴇᴀsᴇ. ᴛʀʏᴘsɪɴᴏɢᴇɴ ᴇɴᴛᴇʀs ᴛʜᴇ sᴍᴀʟʟ ɪɴᴛᴇsᴛɪɴᴇ, ᴠɪᴀ ᴛʜᴇ ᴄᴏᴍᴍᴏɴ ʙɪʟᴇ ᴅᴜᴄᴛ, ᴡʜᴇʀᴇ ɪᴛ ᴄᴏɴᴠᴇʀᴛᴇᴅ ᴛᴏ ᴀᴄᴛɪᴠᴇ ᴛʀʏᴘsɪɴ. ᴛʀʏᴘsɪɴ ᴄʟᴇᴀᴠᴇs ᴀ ᴛᴇʀᴍɪɴᴀʟ ʜᴇxᴀᴘᴇᴘᴛɪᴅᴇ ғʀᴏᴍ ᴛʀʏᴘsɪɴᴏɢᴇɴ ᴛᴏ ʏɪᴇʟᴅ ᴀ sɪɴɢʟᴇ-ᴄʜᴀɪɴ [ʙᴇᴛᴀ]-ᴛʀʏᴘsɪɴ. sᴜʙsᴇǫᴜᴇɴᴛ ᴀᴜᴛᴏʟʏsɪs ᴘʀᴏᴅᴜᴄᴇs ᴏᴛʜᴇʀ ᴀᴄᴛɪᴠᴇ ғᴏʀᴍs ʜᴀᴠɪɴɢ ᴛᴡᴏ ᴏʀ ᴍᴏʀᴇ ᴘᴇᴘᴛɪᴅᴇ ᴄʜᴀɪɴs. ᴛʜᴇ ᴛᴡᴏ ᴘʀᴇᴅᴏᴍɪɴᴀɴᴛ ғᴏʀᴍs ᴏғ ᴛʀʏᴘsɪɴ ᴀʀᴇ [ᴀʟᴘʜᴀ]-ᴛʀʏᴘsɪɴ, ᴡʜɪᴄʜ ʜᴀs ᴛᴡᴏ ᴘᴇᴘᴛɪᴅᴇ ᴄʜᴀɪɴs ʙᴏᴜɴᴅ ʙʏ ᴅɪsᴜʟғɪᴅᴇ ʙᴏɴᴅs, ᴀɴᴅ [ʙᴇᴛᴀ]-ᴛʀʏᴘsɪɴ.
- ᴛʀʏᴘsɪɴ ᴅᴇɢʀᴀᴅᴇs ᴘʀᴏᴛᴇɪɴs. ᴀs ᴛʀʏᴘsɪɴ ɪs ɪᴛsʟғ ᴀ ᴘʀᴏᴛᴇɪɴ, ɪᴛ ɪs ᴄᴀᴘᴀʙʟᴇ ᴏғ ᴅɪɢᴇsᴛɪɴɢ ɪɴsᴇʟғ: ᴀ ᴘʀᴏᴄᴇss ᴄᴀʟʟᴇᴅ ᴀᴜᴛᴏʟʏsɪs. ᴀᴜᴛᴏʟʏsɪs ɪs ɪᴍᴘᴏʀᴛᴀɴᴛ ғᴏʀ ᴛʜᴇ ʀᴇɢᴜʟᴀᴛɪᴏɴ ᴏғ ᴛʀʏᴘsɪɴ ʟᴇᴠᴇʟs ᴡɪᴛʜɪɴ ʟɪᴠɪɴɢ ᴏʀɢᴀɴɪsᴍs. ᴛʜɪs ʀᴇɢᴜʟᴀᴛɪᴏɴ ɪs ᴀssɪsᴛᴇᴅ ʙʏ ᴄᴀ2+ ɪᴏɴs, ᴡʜɪᴄʜ ʙɪɴᴅ ᴛᴏ ᴛʀʏᴘsɪɴ (ᴀᴛ ᴛʜᴇ ᴄᴀ2+-ʙɪɴᴅɪɴɢ ʟᴏᴏᴘ) ᴀɴᴅ ᴘʀᴏᴛᴇᴄᴛ ᴛʜᴇ ᴍᴏʟᴇᴄᴜʟᴇ ᴀɢᴀɪɴsᴛ ᴀᴜᴛᴏʟʏsɪs. ɪɴ ʟɪᴠɪɴɢ ᴏʀɢᴀɴɪsᴍs, ᴀᴜᴛᴏʟʏsɪs ɪs ᴄᴏɴᴛʀᴏʟʟᴇᴅ ᴀɴᴅ ɴᴏʀᴍᴀʟʟʏ ᴅᴏᴇs ɴᴏᴛ ᴄᴀᴜsᴇ ᴘʀᴏʙʟᴇᴍs. ʜᴏᴡᴇᴠᴇʀ, ᴡʜᴇɴ ᴡᴏʀᴋɪɴɢ ᴡɪᴛʜ ᴛʀʏᴘɪɴ ɪɴ ᴠɪᴛʀᴏ, ᴛʜᴇ ᴘʀᴏᴄᴇss ᴏғ ᴀᴜᴛᴏʟʏsɪs ᴏғᴛᴇɴ ᴘᴏsᴇs sᴏᴍᴇ ᴘʀᴏʙʟᴇᴍs. ғᴏʀ ɪɴ ᴠɪᴛʀᴏ ᴘʀᴏᴄᴇssᴇs ᴛʜᴀᴛ ʀᴇǫᴜɪʀᴇ ᴛʜᴇ ᴜsᴇ ᴏғ ᴛʀʏᴘsɪɴ, sᴜᴄʜ ᴀs ᴡᴏʀᴋɪɴɢ ᴡɪᴛʜ ᴄᴇʟʟ ᴄᴜʟᴛᴜʀᴇs ᴏʀ ᴍᴀɴᴜғᴀᴄᴛᴜʀɪɴɢ ɪɴsᴜʟɪɴ, ᴛʀʏᴘsɪɴ's ᴅᴇɢʀᴀᴅᴀᴛɪᴏɴ ᴄᴀɴ ʙᴇᴄᴏᴍᴇ ᴇxᴘᴇɴsɪᴠᴇ ᴀs ᴀᴄᴛɪᴠᴇ ᴛʀʏᴘsɪɴ ɢᴇᴛs "ᴜsᴇᴅ ᴜᴘ." ᴅᴇᴠᴇʟᴏᴘɪɴɢ ᴍᴜᴛᴀɴᴛ ᴛʀʏᴘsɪɴ ᴛʜᴀᴛ ᴅᴏᴇs ɴᴏᴛ ᴀᴜᴛᴏ-ᴅᴇɢʀᴀᴅᴇ ᴄᴏᴜʟᴅ ʙᴇ ᴏғ ɢʀᴇᴀᴛ ᴜsᴇ ғᴏʀ ʀᴇsᴇᴀʀᴄʜᴇʀs.
- ᴛʜᴇʀᴇ ᴀʀᴇ sᴇᴠᴇʀᴀʟ sɪᴛᴇs ᴏɴ ᴛʜᴇ ᴛʀʏᴘsɪɴ ᴍᴏʟᴇᴄᴜʟᴇ ᴀᴛ ᴡʜɪᴄʜ ᴀᴜᴛᴏʟʏsɪs ɪs ᴋɴᴏᴡɴ ᴛᴏ ᴏᴄᴄᴜʀ. ʀᴇsᴇᴀʀᴄʜ ʜᴀs ʙᴇᴇɴ ᴅᴏɴᴇ ᴛᴏ ɪɴᴠᴇsᴛɪɢᴀᴛᴇ ᴛʜᴇsᴇ sɪᴛᴇs, ʙᴇᴄᴀᴜsᴇ ᴛʜᴇ ɪɴᴀʙɪʟɪᴛʏ ᴏғ ᴛʀʏᴘsɪɴ ᴛᴏ sᴇʟғ-ᴅᴇɢʀᴀᴅᴇ ʜᴀs ʙᴇᴇɴ ʟɪɴᴋᴇᴅ ᴛᴏ ʜᴜᴍᴀɴ ʜᴇʀᴇᴅɪᴛᴀʀʏ ᴘᴀɴᴄʀᴇᴀᴛɪᴛɪs. ᴛʜɪs ᴅᴇᴀᴅʟʏ ᴅɪsᴇᴀsᴇ ɪs ʙᴇʟɪᴇᴠᴇᴅ ᴛᴏ ᴏᴄᴄᴜʀ ᴅᴜᴇ ᴛᴏ ɪɴᴀᴘᴘʀᴏᴘʀɪᴀᴛᴇ ᴀᴄᴛɪᴠᴀᴛɪᴏɴ ᴏғ ᴛʀʏᴘsɪɴ ᴡɪᴛʜɪɴ ᴛʜᴇ ᴘᴀɴᴄʀᴇᴀsᴇ. ᴛʜɪs ʀᴇsᴜʟᴛs ɪɴ ᴛʜᴇ ᴀᴜᴛᴏᴅɪɢᴇsᴛɪᴏɴ ᴏғ ᴘᴀɴᴄʀᴇᴀᴛɪᴄ ᴛɪssᴜᴇ. ɪɴ ᴛʜɪs ɪɴᴠᴇsᴛɪɢᴀᴛɪᴏɴ, ᴡᴇ ᴡɪʟʟ ʙᴇ sᴛᴜᴅʏɪɴɢ ʀᴀᴛ (ʀᴀᴛᴛᴜs ʀᴀᴛᴛᴜs) ᴛʀʏᴘsɪɴ ᴀɴᴅ ᴀ ᴍᴜᴛᴀɴᴛ ғᴏʀᴍ ᴏғ ʀᴀᴛ ᴛʀʏᴘsɪɴ, ɪɴ ᴡʜɪᴄʜ ᴛᴡᴏ ᴀᴜᴛᴏʟʏᴛɪᴄ sɪᴛᴇs ʜᴀᴠᴇ ʙᴇᴇɴ ʀᴇᴍᴏᴠᴇᴅ. ᴛʜɪs ᴍᴜᴛᴀɴᴛ ғᴏʀᴍ ᴏғ ᴛʀʏᴘsɪɴ ᴄᴏᴜʟᴅ ʜᴇʟᴘ ʀᴇsᴇᴀʀᴄʜᴇʀs ᴜɴᴅᴇʀsᴛᴀɴᴅ ʜᴇʀᴇᴅɪᴛᴀʀʏ ᴘᴀɴᴄʀᴇᴀᴛɪᴛɪs ᴀɴᴅ ᴄᴏᴜʟᴅ ʙᴇ ᴜsᴇғᴜʟ ғᴏʀ ʀᴇsᴇᴀʀᴄʜ ᴛʜᴀᴛ ɪs ᴅᴇᴘᴇɴᴅᴇɴᴛ ᴜᴘᴏɴ sɪɢɴɪғɪᴄᴀɴᴛ ᴜsᴇ ᴏғ ᴀᴄᴛɪᴠᴇ ᴛʀʏᴘsɪɴ.
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Trypsin is a proteolytic enzyme, important for the digestion of proteins. In humans, the protein is produced in its inactive form, trypsinogen, within the pancrease. Trypsinogen enters the small intestine, via the common bile duct, where it converted to active trypsin.
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