Question

What macrophages in the epidermis are part of the immune system?

Answer 1

Although the epidermis has no direct access to the blood or lymphatic circulation, it is equipped with immune-competent cells: Langerhans cells, the macrophage-like antigen-presenting cells of the epidermis; keratinocytes, epithelial cells with immune properties; dendritic epidermal T lymphocytes, resident cells that .

Answer 2

The key immune cells in the epidermis are: Epidermal dendritic cells (Langerhans cells) Keratinocytes (skin cells).

The dermis has blood and lymph vessels and numerous immune cells, including:

• Dermal dendritic cells.
• Lymphocytes: T cells, B cells, natural killer (NK) cells.
• Mast cells.

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