Question

What major changes did Europe undergo after the outbreak of Bubonic plague?

Answer 1

The spread of disease and trade went hand in hand, and no event illustrates this relationship better than the outbreak of 

bubonic

 plague in the mid-14th century, an event more commonly known today as the Black Death

Plague brought an eventual end of Serfdom in Western Europe. The manorial system was already in trouble, but the Black Death assured its demise throughout much of western and central Europe by 1500. Severe depopulation and migration of the village to cities caused an acute shortage of agricultural labourers.