Question

What molecular mechanism might cause a certain region of chromosomal dna to accidentally undergo amplification?

Answer 1

There are two reasons the transfection focus assay may fail. One of the reasons is that the assay only precipitates out one gene, and if there are two genes required for tumor development, it will not show up. Another reason this assay might not work is that cancer cells may not transform mouse cells due to some interspecies incompatibility. Overexpression alone may not be sufficient for transformation.

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