what role did the Global transfer of smallpox played in the colonization of America
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Answer:
Europeans like Spaniards, Portuguese flowed into America after its discovery.
The germs of smallpox were carried on their person.
The global transfer of disease in the pre-modern world helped in the colonization of the Americas because the native American Indians were not immune to the diseases that the settlers and colonizers brought with them.
The Europeans were more or less immune to smallpox, but the native Americans, having been cut off from the rest of the world for millions of years, had no defence against it. These germs killed and wiped out whole communities, paving the way for foreign domination.
Weapons and soldiers could be destroyed or captured, but diseases could not be fought against. But not diseases such as smallpox to which the conquerors were mostly immune.