What's the expiry of ACD or CPD whole blood and Red blood cells?
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I think rbcs was expired within 4..to ...5 days
Rajasekhar92:
Patients die in Bihar after transfusion with expired blood. The expiration date for ACD or CPD whole blood and red blood cells shall be 21 days from date of collection. The expiration date for frozen blood cells is 3 years from the date of donation, stored at -65°C or colder.
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The first anticoagulant preservative was introduced by Rous and Turner in 1916. It consisted of a citrate-glucose solution in which blood from rabbits was stored for two weeks, which prevented anaemia when transfused in another rabbit who had suffered from blood loss. Rous Turner's solution as used for storage of human blood during the First World War (Mollison 1987). The next important development occurred in 1943 during the Second World War when acidifieditrate dextrose (ACD) solution was introduced for clinical use by Loutit and Mollison.In 1957 Gibson et al developed an improved preservative of citrate-phosphate-dextrose (CPD), which was less acidic than ACD and maintained 2,3-diphosphoglycerate (2,3-DPG) level better than in ACD solution. CPD eventually replaced ACD and became commonly used preservative for storage of blood/red cells in liquid form. Shelf-life of blood stored in CPD at 2-4 °C was 21 day.
In 1978 citrate-phosphate-dextrose with adenine (CPDA-1) preservative was developed. The addition of adenine improved the synthesis of adenosine triphosphate (ATP) in the stored blood,which prolonged the storage of blood/red cells at 2-4 °C to 35 days.
In 1978 citrate-phosphate-dextrose with adenine (CPDA-1) preservative was developed. The addition of adenine improved the synthesis of adenosine triphosphate (ATP) in the stored blood,which prolonged the storage of blood/red cells at 2-4 °C to 35 days.
Patients die in Bihar after transfusion with expired blood. The expiration date for ACD or CPD whole blood and red blood cells shall be 21 days from date of collection. The expiration date for frozen blood cells is 3 years from the date of donation, stored at -65°C or colder.
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