What stops the function of the citric acid cycle and the respiratory chain?
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Pyruvate from glycolysis does not enter directly into the citric acid cycle. First it passes through a “transition phase” where it is undergoes oxidative decarboxylation to CO2 at the hands of the pyruvate dehydrogenase complex, transferring acetyl groups to coenzyme A to yield acetyl-CoA.
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Explanation:
☑️ The citric acid cycle is regulated primarily by the concentration of ATP and NADH. The key control points are the enzymes isocitrate dehydrogenase and α-ketoglutarate dehydrogenase. In contrast, NADH inhibits iso-citrate dehydrogenase by directly displacing NAD+.
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