What type of measures based to predict or detect tumors?
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Detection can be done either in tissue or in body fluids like ascitic or pleural fluid or serum.
Clinical uses can be broadly classified into 4 groups:
screening and early detection,
diagnostic confirmation,
prognosis and prediction of therapeutic response and
monitoring disease and recurrence.
In addition to variable sensitivity and specificity, the prevalence of a particular malignancy may be a major determinant in the application of a particular test as a screening tool.
Serum levels, in certain situations, can be used in staging, prognostication or prediction of response to therapy. Rising trend in serum levels may detect recurrence of disease well before any clinical or radiological evidence of disease is apparent.
Monitoring disease is, perhaps, the most common clinical use of serum tumor markers. Rising trend in serum levels may detect recurrence of disease well before any clinical or radiological evidence of disease is apparent.
Sampling should ideally be repeated after 5-6 half-lives of the marker in question; but if found elevated, the next sampling after 2-4 weeks, for additional evidence, may be justified.
Clinical uses can be broadly classified into 4 groups:
screening and early detection,
diagnostic confirmation,
prognosis and prediction of therapeutic response and
monitoring disease and recurrence.
In addition to variable sensitivity and specificity, the prevalence of a particular malignancy may be a major determinant in the application of a particular test as a screening tool.
Serum levels, in certain situations, can be used in staging, prognostication or prediction of response to therapy. Rising trend in serum levels may detect recurrence of disease well before any clinical or radiological evidence of disease is apparent.
Monitoring disease is, perhaps, the most common clinical use of serum tumor markers. Rising trend in serum levels may detect recurrence of disease well before any clinical or radiological evidence of disease is apparent.
Sampling should ideally be repeated after 5-6 half-lives of the marker in question; but if found elevated, the next sampling after 2-4 weeks, for additional evidence, may be justified.
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