Question

What type of mutation is caused by an insertion or deletion of a base and results in a change of the entire sequence after the point of insertion or deletion?

Answer 1

An insertion mutation occurs when an extra nucleotide is added to the DNA strand during replication. This can happen when the replicating strand "slips," or wrinkles, which allows the extra nucleotide to be incorporated (Figure 2). Strand slippage can also lead to deletion mutations.