What will be the PI value if the Pka value of carboxyl group of aspartic acid is 2.1 and Pka value of amino groups is 9.8 and that of R group is 3.9 ?
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These amino acids are characterised by two pKas : pKa1 and pKa2 for the carboxylic acid and the amine respectively.
The isoelectronic point will be halfway between, or the average of, these two pKas, i.e. pI = 1/2 (pKa1 + pKa2). This is most readily appreciated when you realise that at very acidic pH (below pKa1) the amino acid will have an overall +ve charge and at very basic pH (above pKa2 ) the amino acid will have an overall -ve charge. For the simplest amino acid, glycine, pKa1= 2.34 and pKa2 = 9.6, pI = 5.97.
The other two cases introduce other ionisable groups in the side chain "R" described by a third acid dissociation constant, pKa3
Explanation:
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