What would cause an error in DNA replication?
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When Replication Errors Become Mutations. Incorrectly paired nucleotides that still remain following mismatch repair become permanent mutations after the next cell division. This is because once such mistakes are established, the cell no longer recognizes them as errors.
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Errors during DNA replication are not the only reason why mutations arise in DNA. Mutations, variations in the nucleotide sequence of a genome, can also occur because of damage to DNA. ... The most common nucleotide mutations are substitutions, in which one base is replaced by another.
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