when an amino group and carboxylic group present in the same molecule react intramolecular the resulting amide is called
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The direct reaction of a carboxylic acid with an amine would be expected to be difficult because the basic amine would deprotonate the carboxylic acid to form a highly unreactive carboxylate. However when the ammonium carboxylate salt is heated to a temperature above 100 ℃ water is driven off and an amide is formed
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