When are polymorphs and macrophages could be maximum in liver?
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6 ANSWERS

Neelu Maini, Founder and CEO (2015-present)
Answered Feb 24, 2017 · Author has 92 answers and 189.5k answer views
A type of WBC (white blood cells) is referred to as Polymorphonuclear Leucocytes or Granulocytes. They contain granules. They are named so because of the varying shape of their nucleus. They are again of three types namely Neutrophils, Eosinophils and Basophils.
However, in common man’s language, by polymorth they usually refer to the Neutrophils, that are present in the highest number as compared to other PMNL(Polymorphonuclear Leucocytes) such as Eosinophils and basophils.
Temporary or transient increase under normal circumstances may occur in case of acute stress or after heavy exercise.
Increased number of neutrophils under pathological or diseased condition signal:
Infection, Bacterial
Any acute inflammation
Tissue destruction or death(necrosis) as in Infarction(heart attack), burns, neoplasia(tumor)
Liver diseases are one of the main causes of mortality. In this regard, the development of new ways of reparative processes stimulation is relevant. Macrophages play a leading role in the regulation of liver homeostasis in physiological conditions and in pathology. In this regard, the development of new liver treatment methods is impossible without taking into account this cell population. Resident macrophages of the liver, Kupffer cells, represent a unique cell population, first of all, due to their development. Most of the liver macrophages belong to the self-sustaining macrophage cell population, whose origin is not bone marrow. In addition, Kupffer cells are involved in such processes as regulation of hepatocyte proliferation and apoptosis, remodeling of the intercellular matrix, lipid metabolism, protective function, etc. Such a broad spectrum of liver macrophage functions indicates their high functional plasticity. The review summarizes recent data on the development, phenotypic and functional plasticity, and participation in the reparative processes of liver macrophages: resident macrophages (Kupffer cells) and bone marrow-derived macrophages.
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