Question

When cell has stalled dna replication fork which checkpoint should be predominantly activated?

Answer 1

Answer:

Chk1 and Chk2

Explanation:

When the fork stalls or breaks, the cell sequentially activates signal transduction proteins to ensure that offspring inherit accurate copies of parental DNA. Atop this system stand the ATM/ATR related protein kinases, which transduce the signal to arrest the cell cycle. ATR and ATM phosphorylate downstream kinases such as Chk1 and Chk2 are important to inactivate the cell cycle engine, CDK1, by inhibiting Cdc25 and activating Wee1 (Carr 2002; Nyberg et al. 2002; Boddy & Russell 2001). These activities prevent the cell from moving into the later phases of the cell cycle, ensuring that the cells do not pass on incomplete or altered genetic information to the daughter cells.