Question

When cells leave the cell cycle, they exit during G1 phase and then enter G0 phase, a resting period. Most normal cells can leave G0 phase and reenter the cell cycle at G1 phase before entering S phase. Cancer cells are different because they cannot enter G0 phase and are likely to do which of the following?

Answer 1

what is the answer

G0 is a non-dividing phase of the cell cycle where the cell is not preparing to replicate. Cells may enter G0 during G1 and remain for the rest of their life, or a signal may cause them to re-enter G1 and continue in the cell cycle.

Consider two cells: a stomach-lining epithelial cell dividing more than twice a day and a liver cell dividing every year or two. Which cell is likely to be in G0 phase and why?

Explanation:

Answer 2

Cancer cells are different from normal cells because they cannot enter the G₀ phase and are likely to keep repeating the cell cycle continuously.

Although the options in your question are missing, you might be referring to this question:

The diagram below represents the cell cycle.

When cells leave the cell cycle, they exit during the G₁ phase and then enter the G₀ phase, a resting period. Most normal cells can leave the G₀ phase and reenter the cell cycle at the G₁ phase before entering the S phase. Cancer cells are different because they cannot enter the G₀ phase and are likely to do which of the following?

1. Fail to complete S phase
2. Mutate during G1 phase
3. Repeat the cell cycle continuously
4. Die after completing mitosis

What is the G₀ phase?

• The G₀ phase of the cell cycle is a quiescent/dormant phase in which the cell suspends its cell cycle.
• This phase can be entered after the G₁ phase.

How are cancer cells different from normal cells?

• Cancer cells are different from normal cells in the following properties:

1. Loss of Contact Inhibition

• Contact Inhibition is the property of cells that stops them from proliferating on other cells in their vicinity.
• Cancer cells lose this property, hence their growth becomes uncontrollable.
• They start multiplying on top of cells in their vicinity, leading to the growth of a tumor.
• Thus, these cells repeat the cell cycle continuously.

2. Metastasis

• If cancer cells multiply enough to form a malignant tumor, then they can move to other parts of the body and start a tumor there.
• This property of cancer cells is called metastasis.

3. Requirement of More Nutrients

• Since cancer cells multiply more rapidly than normal cells, thus their demands for proteins, carbohydrates, nutrients, etc increase.

Thus, in terms of multiplication, cancer cells are likely to keep repeating the cell cycle.