When the cuff pressure is high enough to keep the brachial artery closed, no blood flows through it and no sound is heard. When cuff pressure decreases and is no longer able to keep the artery closed, blood is pushed through, producing turbulent blood flow and a sound. Systolic pressure is the pressure at which the first korotkoff sound is heard. At first, the artery is closed during systole but as cuff pressure continues to decrease, the artery partially opens. Turbulent blood flow during systole produces pulse sounds, although the pitch of the sounds changes as the artery becomes more open?
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Memory-based acquired immunity evolved in higher vertebrates based
on the ability to differentiate foreign organisms (e.g., pathogens) from self-
cells. While we still do not understand the basis of this, two corollaries of
this ability have to be understood. One, higher vertebrates can distinguish
foreign molecules as well as foreign organisms. Most of the experimental
immunology deals with this aspect. Two, sometimes, due to genetic and
other unknown reasons, the body attacks self-cells. This results in damage
to the body and is called auto-immune disease. Rheumatoid arthritis
which affects many people
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