Question

Which analytical technique would be useful for clinical significance?

Answer 1

Clinical significance refers to changes that are clinically meaningful for individuals as they progress through a course of treatment. Since the first method of assessing clinical significance was proposed, a number of alternatives have been suggested, each purporting to increase sensitivity for detecting meaningful change. However, few comparisons have been conducted on these methods, and there is little evidence for any method's predictive validity. This study compares classification rates of five clinical significance methods with participants treated for major depressive disorder (N = 128). It also compares the methods' accuracy in predicting relapse of depression 2 years posttreatment. Although all methods successfully predicted relapse from chance discrimination, no significant differences emerged between methods. Implications for future research are discussed

Answer 2

Analytical Techniques, Pharmaceutical Analysis, Classification of Analytical Techniques, Various Analytical Techniques, Volumetric Analysis, Acid-base titration, complexometric titrations, precipitation titrations, redox titrations, Chromatographic Techniques, Spectral Analysis, Mass Spectroscopy, Electrochemical

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