which antibiotic is most effective for organism producing aminoglycoside inactivating enzymes ?
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Most efforts have been directed towards the APH(3′) enzymes, which inactivate kanamycin and other aminoglycosides carrying a 3′-OH function such as amikacin and isepamicin. They make up to 2% of the total bacterial protein (92, 93) and exist in several subgroups.
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