Which cells help in the formation of ameloblasts ?
Answers
ᴀᴍᴇʟᴏʙʟᴀsᴛs ᴀʀᴇ ᴄᴇʟʟs ᴡʜɪᴄʜ sᴇᴄʀᴇᴛᴇ ᴛʜᴇ ᴇɴᴀᴍᴇʟ ᴘʀᴏᴛᴇɪɴs ᴇɴᴀᴍᴇʟɪɴ ᴀɴᴅ ᴀᴍᴇʟᴏɢᴇɴɪɴ ᴡʜɪᴄʜ ᴡɪʟʟ ʟᴀᴛᴇʀ ᴍɪɴᴇʀᴀʟɪᴢᴇ ᴛᴏ ғᴏʀᴍ ᴇɴᴀᴍᴇʟ, ᴛʜᴇ ʜᴀʀᴅᴇsᴛ sᴜʙsᴛᴀɴᴄᴇ ɪɴ ᴛʜᴇ ʜᴜᴍᴀɴ ʙᴏᴅʏ.
ᴇᴀᴄʜ ᴀᴍᴇʟᴏʙʟᴀsᴛ ɪs ᴀ ᴄᴏʟᴜᴍɴᴀʀ ᴄᴇʟʟ ᴀᴘᴘʀᴏxɪᴍᴀᴛᴇʟʏ 4 ᴍɪᴄʀᴏᴍᴇᴛᴇʀs ɪɴ ᴅɪᴀᴍᴇᴛᴇʀ, 40 ᴍɪᴄʀᴏᴍᴇᴛᴇʀs ɪɴ ʟᴇɴɢᴛʜ ᴀɴᴅ ɪs ʜᴇxᴀɢᴏɴᴀʟ ɪɴ ᴄʀᴏss sᴇᴄᴛɪᴏɴ. ᴛʜᴇ sᴇᴄʀᴇᴛᴏʀʏ ᴇɴᴅ ᴏғ ᴛʜᴇ ᴀᴍᴇʟᴏʙʟᴀsᴛ ᴇɴᴅs ɪɴ ᴀ sɪx-sɪᴅᴇᴅ ᴘʏʀᴀᴍɪᴅ-ʟɪᴋᴇ ᴘʀᴏᴊᴇᴄᴛɪᴏɴ ᴋɴᴏᴡɴ ᴀs ᴛʜᴇ ᴛᴏᴍᴇs' ᴘʀᴏᴄᴇss. ᴛʜᴇ ᴀɴɢᴜʟᴀᴛɪᴏɴ ᴏғ ᴛʜᴇ ᴛᴏᴍᴇs' ᴘʀᴏᴄᴇss ɪs sɪɢɴɪғɪᴄᴀɴᴛ ɪɴ ᴛʜᴇ ᴏʀɪᴇɴᴛᴀᴛɪᴏɴ ᴏғ ᴇɴᴀᴍᴇʟ ʀᴏᴅs, ᴛʜᴇ ʙᴀsɪᴄ ᴜɴɪᴛ ᴏғ ᴛᴏᴏᴛʜ ᴇɴᴀᴍᴇʟ. ᴅɪsᴛᴀʟ ᴛᴇʀᴍɪɴᴀʟ ʙᴀʀs ᴀʀᴇ ᴊᴜɴᴄᴛɪᴏɴᴀʟ ᴄᴏᴍᴘʟᴇxᴇs ᴛʜᴀᴛ sᴇᴘᴀʀᴀᴛᴇ ᴛʜᴇ ᴛᴏᴍᴇs' ᴘʀᴏᴄᴇssᴇs ғʀᴏᴍ ᴀᴍᴇʟᴏʙʟᴀsᴛ ᴘʀᴏᴘᴇʀ.
ᴅᴇᴠᴇʟᴏᴘᴍᴇɴᴛ ᴇᴅɪᴛ
ᴀᴍᴇʟᴏʙʟᴀsᴛs ᴀʀᴇ ᴅᴇʀɪᴠᴇᴅ ғʀᴏᴍ ᴏʀᴀʟ ᴇᴘɪᴛʜᴇʟɪᴜᴍ ᴛɪssᴜᴇ ᴏғ ᴇᴄᴛᴏᴅᴇʀᴍᴀʟ ᴏʀɪɢɪɴ. ᴛʜᴇɪʀ ᴅɪғғᴇʀᴇɴᴛɪᴀᴛɪᴏɴ ғʀᴏᴍ ᴘʀᴇᴀᴍᴇʟᴏʙʟᴀsᴛs (ᴡʜᴏsᴇ ᴏʀɪɢɪɴ ɪs ғʀᴏᴍ ɪɴɴᴇʀ ᴇɴᴀᴍᴇʟ ᴇᴘɪᴛʜᴇʟɪᴜᴍ) ɪs ᴀ ʀᴇsᴜʟᴛ ᴏғ sɪɢɴᴀʟɪɴɢ ғʀᴏᴍ ᴛʜᴇ ᴇᴄᴛᴏᴍᴇsᴇɴᴄʜʏᴍᴀʟ ᴄᴇʟʟs ᴏғ ᴛʜᴇ ᴅᴇɴᴛᴀʟ ᴘᴀᴘɪʟʟᴀ. ɪɴɪᴛɪᴀʟʟʏ ᴛʜᴇ ᴘʀᴇᴀᴍᴇʟᴏʙʟᴀsᴛs ᴡɪʟʟ ᴅɪғғᴇʀᴇɴᴛɪᴀᴛᴇ ɪɴᴛᴏ ᴘʀᴇsᴇᴄʀᴇᴛᴏʀʏ ᴀᴍᴇʟᴏʙʟᴀsᴛs ᴀɴᴅ ᴛʜᴇɴ ɪɴᴛᴏ sᴇᴄʀᴇᴛᴏʀʏ ᴀᴍᴇʟᴏʙʟᴀsᴛs ᴡʜɪᴄʜ ʟᴀʏ ᴅᴏᴡɴ ᴛʜᴇ ᴛᴏᴏᴛʜ ᴇɴᴀᴍᴇʟ. ᴛʜᴇ ᴅɪғғᴇʀᴇɴᴛɪᴀᴛɪᴏɴ ғʀᴏᴍ ᴘʀᴇᴀᴍᴇʟᴏʙʟᴀsᴛs ᴛᴏ ᴀᴍᴇʟᴏʙʟᴀsᴛs ᴏᴄᴄᴜʀs ᴅᴜʀɪɴɢ ᴛʜᴇ ғɪʀsᴛ sᴛᴀɢᴇ ᴏғ ᴀᴍᴇʟᴏɢᴇɴᴇsɪs, ᴄᴀʟʟᴇᴅ ᴛʜᴇ ᴘʀᴇ-sᴇᴄʀᴇᴛᴏʀʏ (ᴏʀ ɪɴᴅᴜᴄᴛɪᴠᴇ) ᴘʜᴀsᴇ.
ᴛʜᴇ ᴀᴍᴇʟᴏʙʟᴀsᴛs ᴡɪʟʟ ᴏɴʟʏ ʙᴇᴄᴏᴍᴇ ғᴜʟʟʏ ғᴜɴᴄᴛɪᴏɴᴀʟ ᴀғᴛᴇʀ ᴛʜᴇ ғɪʀsᴛ ʟᴀʏᴇʀ ᴏғ ᴅᴇɴᴛɪɴ (ᴘʀᴇᴅᴇɴᴛɪɴ) ʜᴀs ʙᴇᴇɴ ғᴏʀᴍᴇᴅ ʙʏ ᴏᴅᴏɴᴛᴏʙʟᴀsᴛs. ᴛʜᴇ ᴄᴇʟʟs ᴀʀᴇ ᴘᴀʀᴛ ᴏғ ᴛʜᴇ ʀᴇᴅᴜᴄᴇᴅ ᴇɴᴀᴍᴇʟ ᴇᴘɪᴛʜᴇʟɪᴜᴍ ᴀғᴛᴇʀ ᴇɴᴀᴍᴇʟ ᴍᴀᴛᴜʀᴀᴛɪᴏɴ ᴀɴᴅ ᴛʜᴇɴ sᴜʙsᴇϙᴜᴇɴᴛʟʏ ᴜɴᴅᴇʀɢᴏ ᴀᴘᴏᴘᴛᴏsɪs ʙᴇғᴏʀᴇ ᴏʀ ᴀғᴛᴇʀ ᴛᴏᴏᴛʜ ᴇʀᴜᴘᴛɪᴏɴ.:103 ᴛʜᴇsᴇ sᴛᴀɢᴇs ᴏᴄᴄᴜʀ ᴅᴜʀɪɴɢ ᴛʜᴇ ᴛʜɪʀᴅ ᴀɴᴅ ғɪɴᴀʟ sᴛᴀɢᴇ ᴏғ ᴀᴍᴇʟᴏɢᴇɴᴇsɪs, ᴄᴀʟʟᴇᴅ ᴛʜᴇ ᴍᴀᴛᴜʀᴀᴛɪᴏɴ ᴘʜᴀsᴇ.
ᴛʜᴇʀᴇ ᴀʀᴇ ᴠᴀʀɪᴏᴜs ғᴀᴄᴛᴏʀs ᴡʜɪᴄʜ ᴄᴀɴ ᴀғғᴇᴄᴛ ᴛʜᴇ ᴅɪғғᴇʀᴇɴᴛɪᴀᴛɪᴏɴ ᴀɴᴅ ᴅᴇᴠᴇʟᴏᴘᴍᴇɴᴛ ᴏғ ᴀᴍᴇʟᴏʙʟᴀsᴛs, ᴄᴀᴜsɪɴɢ ᴀʙɴᴏʀᴍᴀʟɪᴛɪᴇs ᴛᴏ ғᴏʀᴍ ᴡɪᴛʜɪɴ ᴛʜᴇ ᴛᴏᴏᴛʜ sᴛʀᴜᴄᴛᴜʀᴇ. ᴏɴᴇ ᴇxᴀᴍᴘʟᴇ ɪs ᴛʜᴇ ʙᴍᴘ (ʙᴏɴᴇ ᴍᴏʀᴘʜᴏɢᴇɴᴇᴛɪᴄ ᴘʀᴏᴛᴇɪɴ,) ᴡʜɪᴄʜ ʜᴀs ᴀɴ ɪᴍᴘᴏʀᴛᴀɴᴛ ʀᴏʟᴇ ɪɴ ᴀᴍᴇʟᴏʙʟᴀsᴛ ᴅɪғғᴇʀᴇɴᴛɪᴀᴛɪᴏɴ. ᴡʜᴇɴ ғᴏʟʟɪsᴛᴀᴛɪɴ, ᴀ ʙᴍᴘ ɪɴʜɪʙɪᴛᴏʀ, ɪs ᴏᴠᴇʀ ᴇxᴘʀᴇssᴇᴅ ɪɴ ᴛʜᴇ ᴇᴘɪᴛʜᴇʟɪᴜᴍ ᴏғ ᴅᴇᴠᴇʟᴏᴘɪɴɢ ᴛᴇᴇᴛʜ, ᴛʜᴇ ᴀᴍᴇʟᴏʙʟᴀsᴛs ᴅᴏ ɴᴏᴛ ᴅɪғғᴇʀᴇɴᴛɪᴀᴛᴇ ᴀɴᴅ ɴᴏ ᴇɴᴀᴍᴇʟ ғᴏʀᴍs. ᴀɴᴏᴛʜᴇʀ ᴇxᴀᴍᴘʟᴇ ɪɴᴄʟᴜᴅᴇs ᴛʜᴇ ᴄᴏɴᴅɪᴛɪᴏɴᴀʟ ᴅᴇʟᴇᴛɪᴏɴ ᴏғ 'ᴅɪᴄᴇʀ-1' ɪɴ ᴛʜᴇ ᴇᴘɪᴛʜᴇʟɪᴜᴍ ᴏғ ᴅᴇᴠᴇʟᴏᴘɪɴɢ ᴛᴇᴇᴛʜ ᴍᴀʏ ᴄᴀᴜsᴇ ɪᴍᴘᴀɪʀᴇᴅ ᴅɪғғᴇʀᴇɴᴛɪᴀᴛɪᴏɴ ᴏғ ᴀᴍᴇʟᴏʙʟᴀsᴛs ᴡʜɪᴄʜ ʀᴇsᴜʟᴛs ɪɴ ᴅᴇғɪᴄɪᴇɴᴛ ᴇɴᴀᴍᴇʟ ғᴏʀᴍᴀᴛɪᴏɴ.
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