Question

which changes in amino acid lead to sickle cell anemia ?​

Answer 1

Explanation:

The most common cause of sickle-cell anemia is a single amino acid mutation in the beta (B) chain of human Hemoglobin from a Glutamic Acid (Glu, E) to a Valine (Val, V). This is amino acid number 6 in the B chain sequence. The sickle cell version of hemoglobin beta is called Hemoglobin S.

Answer 2

Explanation:

The most common cause of sickle-cell anemia is a single amino acid mutation in the beta (B) chain of human Hemoglobin from a Glutamic Acid (Glu, E) to a Valine (Val, V). This is amino acid number 6 in the B chain sequence. The