Question

which drug can be determined by alkalimetric non aqueous titration​

Answer 1

Explanation:

For sulfa drugs, the acidimetric method is faster and more accurate than the nitrite method usually employed. c acid-base titrations in nonaqueous solvents.

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Answer 2

Answer:

• Toluene-Methanol Potassium Methoxide
• Solution of Methoxide
• Cognate Assays
• Hydroxide of tetrabutylammonium

Explanation:

• Using an appropriate non-aqueous solvent with a sharp end-point, a variety of weakly acidic medicinal compounds can be titrated efficiently. Anhydrides, acids, amino acids, acid halides, enols (i.e. barbiturates), xanthines, sulphonamides, phenols, imides, and organic salts of inorganic acids are among the extensive range of organic compounds.
• A weak inorganic acid, such as boric acid, can be easily approximated using ethylenediamine as the non-aqueous solvent.
• 1. Toluene-Methanol Preparation of 0.1 N Potassium Methoxide:
• Materials needed: 40 mL absolute methanol; 50 mL dry toluene; 4 g potassium metal
• 2. 0.1 N Methoxide Solution Standardization:
• Dimethylformamide (DMF): 10 mL; thymol blue (0.3 percent in MeOH): 0.3 g; 0.1 N lithium methoxide in toluene-methanol: 0.6 g; benzoic acid: 0.6 g
• 3. Cognate Assays:
• The following measurements can be made with 0.1 N sodium hydroxide, either titrimetrically with a suitable indicator or potentiometrically.
• 4. Hydroxide of tetrabutylammonium:
• Tetrabutylammonium hydroxide, in combination with an adequate indicatior, can be used to perform alkalimetry in non-aqueous titrations.

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