Question

Which group is of paramount importance for activity in the Site Tacting diuretics?
Chlorine
B
Sulfamoyl
C
amino
bromo​

Answer 1

Answer:

The primary target of hydrochlorothiazide (and other thiazide/thiazide-like diuretics) is the sodium-chloride symporter (SLC12A3, NCC) on the apical membrane of the renal distal tubule. Hydrochlorothiazide is transported from the blood to its site of action by the renal proximal tubule organic acid secretory pathway.