which interaction occurs when metronidazole given with warfarin
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The metabolism of metronidazole is largely undetermined. The available evidence suggests metronidazole inhibits CYP2C9, the enzyme responsible for S-warfarin metabolism. Delayed metabolism of warfarin enhances the anticoagulant effect and increases the likelihood of bleeding complications.
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The metabolism of metronidazole is largely undetermined. The available evidence suggests metronidazole inhibits CYP2C9, the enzyme responsible for S-warfarin metabolism. Delayed metabolism of warfarin enhances the anticoagulant effect and increases the likelihood of bleeding complications.
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