Biology, asked by ariko4455, 8 months ago

Which is a point mutation and not a frameshift mutation?

Answers

Answered by AravindhPrabu2005
8

point mutation

A point mutation is when a single base pair is altered. Point mutations can have one of three effects. ... Second, the base substitution can be a missense mutation where the altered codon corresponds to a different amino acid.

For example, sickle-cell disease is caused by a single point mutation (a missense mutation) in the beta-hemoglobin gene that converts a GAG codon into GUG, which encodes the amino acid valine rather than glutamic acid. ... These are both examples of a non-conservative (missense) mutation.

frameshift mutation

Frameshift mutations are apparent in severe genetic diseases such as Tay–Sachs disease; they increase susceptibility to certain cancers and classes of familial hypercholesterolaemia; in 1997,a frameshift mutation was linked to resistance to infection by the HIV retrovirus. Frameshift mutations have been proposed as a source of biological novelty, as with the alleged creation of nylonase, however, this interpretation is controversial. A study by Negoro et al (2006) [4] found that a frameshift mutation was unlikely to have been the cause and that rather a two amino acid substitution in the active site of an ancestral esterase resulted in nylonase.

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