Question

which is involved in the synthesis of phospholipids​

Answer 1

Answer : Phospholipid biosynthesis is linked to glycolysis through the use of dihydroxyacetone phosphate (DHAP), formed from sn-glycerol-3-phosphate (Gro-3-P) via its reduction by NADH, catalyzed by glycerophosphate dehydrogenase.

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Answer 2

Answer:

Phospholipid synthesis is also called membrane biogenesis which occurs in the smooth endoplasmic reticulum. Acetyl CoA along with Choline and Diacylglycerol are the major components involved in the synthesis of phospholipids.

Explanation:

• Acetyl Co-A are produced in the cytosol through glycolytic pathway and gets converted into fatty acid through several reduction and dehydration steps by combining with the malonyl-CoA in the presence of cytosolic enzyme.
• Then , fatty acid combines with CoA with the help of CoA transferase enzyme and it reacts with glycerol phosphate to form phosphatidic acid. This reaction is mediated by acyl transferases and then the phosphatase enzyme removes the phosphate from phosphatidic acid and converts it into Diacylglycerol.
• And in the ER membrane, choline transferase enzymes are present which catalyzes the reaction between CDP choline and Diacylglycerol. This reaction forms the phosphatidyl choline and at the end phospholipids are formed and choline group is removed by flippase enzyme.

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