Question

Which is the most stable form of dna under normal physiological conditions

a. a-dna

b. b-dna

c.z-dna

d. h-dna?

Answer 1

B DNA represents the most stable structure under physiological conditions.DNA in solution has a average 10.5bp per turn of helix.B form is an average structure,however real DNA is not perfectly regular. 

Answer 2

Under normal physiological conditions, B-DNA is most stable. (option b)

• B- DNA is said while describing the Watson-Crick double-helical structure.
• It is the most stable and predominant form under physiological conditions.
• In this form, two long polynucleotide strands coiled around an axis to form a right-handed helix.
• Strands are antiparallel, i.e., one strand is directed in the 5' → 3' direction and the other in the 3' → 5' direction.
• Strands interact by H-bonds between complementary base pairs.
• Base G forms three hydrogen bonds with C and A forms two hydrogen bonds with T.
• The bases occupy the helix core, and sugar-phosphate chains run along the periphery, minimizing the repulsions between charged phosphate groups.
• Thus option b is correct.

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