which maintains the stability of DNA in prokaryotes when uncoiling has been done in DNA
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Prokaryotic and eukaryotic DNA helicases
Prokaryotic and eukaryotic DNA helicasesEssential molecular motor proteins for cellular machinery
Prokaryotic and eukaryotic DNA helicasesEssential molecular motor proteins for cellular machineryNarendra Tuteja and Renu Tuteja
Prokaryotic and eukaryotic DNA helicasesEssential molecular motor proteins for cellular machineryNarendra Tuteja and Renu TutejaAdditional article information
Prokaryotic and eukaryotic DNA helicasesEssential molecular motor proteins for cellular machineryNarendra Tuteja and Renu TutejaAdditional article informationAbstract
Prokaryotic and eukaryotic DNA helicasesEssential molecular motor proteins for cellular machineryNarendra Tuteja and Renu TutejaAdditional article informationAbstractDNA helicases are ubiquitous molecular motor proteins which harness the chemical free energy of ATP hydrolysis to catalyze the unwinding of energetically stable duplex DNA, and thus play important roles in nearly all aspects of nucleic acid metabolism, including replication, repair, recombination, and transcription. They break the hydrogen bonds between the duplex helix and move unidirectionally along the bound strand. All helicases are also translocases and DNA‐dependent ATPases. Most contain conserved helicase motifs that act as an engine to power DNA unwinding. All DNA helicases share some common properties, including nucleic acid binding, NTP binding and hydrolysis, and unwinding of duplex DNA in the 3′ to 5′ or 5′ to 3′ direction. The minichromosome maintenance (Mcm) protein complex (Mcm4/6/7) provides a DNA‐unwinding function at the origin of replication in all eukaryotes and may act as a licensing factor for DNA replication
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