Question

Which method are used to
determination of primary amines? *
O Diazotization titration
O Karl Fischer titration
O OFC
O All of the above​

Answer 1

Answer:

Spectrophotometric method

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Answer 2

Answer:

The method used to determine the primary amines is (a)Diazotization Titration

Explanation:

• Diazotization is generally used in the analysis of aromatic compounds containing an amino group in the molecules

• It is commonly used to distinguish Aliphatic primary  amines from aromatic primary  amines

Diazo compounds: Compounds with general formula $Ar-N=N-X$ in which the diazo compound ( $-N=N$  ) is bound to the groups on either side of covalency are known as diazo-compounds

• The process of formation of a diazonium salt by the interaction of aromatic primary amine, sodium nitrite, and an organic acid at low temperature, preferably around 0°C is known as Diazotization.

 $C_{6} H_{5} NH_{2} + 2HCl +NaNO_{2}$  →  $C_{6} H_{5} N_{2} Cl + NaCl + 2H_{2} O$

     Aniline                                 Benzenediazonium Chloride

Application:

• Pharmaceutical application of sodium nitrite titration is the analysis of sulphonamides by diazotization of the primary aromatic amino group present in this class of drug.