Which of the anticancer drugs act at
specific sites ----Binas tubulin and
inhibit microtubule formation...
5FU
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Drugs that disrupt microtubule/tubulin dynamics are used widely in cancer chemotherapy. ... Taxanes, including paclitaxel and docetaxel, bind to polymerized microtubules at the inner surface of the β subunit, and are widely used in the treatment of lung, breast, ovarian and bladder cancers.
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E7010 is the most active of sulfonamide antimitotic agent, which has been shown to inhibit microtubule formation by binding at the site of colchicines. ... 2-methoxyestradiol is cytotoxic to several tumor cell lines, binds to the colchicine site of tubulin, inducing the formation of abnormal microtubules.
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