Which of the following causes nanoparticles to accumulate more in tumor cells than in healthy cells?
nanoimprint lithography
molecular beam epitaxy
enhanced permeability and retention
injectable optoelectronic devices
Answers
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nanoimprint lithography
Question:
Which of the following causes nanoparticles to accumulate more in tumor cells than in healthy cells?
Answer:
nano-imprint lithography
Explanation:
Biological barriers to drug transport prevent successful accumulation of nano-therapeutics specifically at diseased sites, limiting efficacious responses in disease processes ranging from cancer to inflammation. Although substantial research efforts have aimed to incorporate multiple functionalities and moieties within the overall nanoparticle design, many of these strategies fail to adequately address these barriers. Obstacles, such as nonspecific distribution and inadequate accumulation of therapeutics, remain formidable challenges to drug developers. A reimagining of conventional nanoparticles is needed to successfully negotiate these impediments to drug delivery. Site-specific delivery of therapeutics will remain a distant reality unless nanocarrier design takes into account the majority, if not all, of the biological barriers that a particle encounters upon intravenous administration. By successively addressing each of these barriers, innovative design features can be rationally incorporated that will create a new generation of nanotherapeutics, realizing a paradigmatic shift in nanoparticle-based drug delivery.